Renuva can be used anywhere fat naturally exists in the body and has been documented across multiple anatomical sites including the face, neck, hands, and body, with peer-reviewed evidence in delicate facial areas including the temples.¹˒⁶

Renuva is processed by MTF Biologics, a global nonprofit organization, with 39+ years of work in tissue donation and processing. Each unit is single-donor sourced and undergoes a validated aseptic process to remove lipids, cells, and DNA.¹

Once Renuva has been gradually replaced by the patient's own fat tissue (typically over 3 to 6 months), the restored volume behaves like the patient's natural fat. A 2024 single-patient case study demonstrated evidence of soft tissue augmentation persisting up to 8 years.⁴

Renuva works by giving the body a scaffold to remodel fat tissue. Tissue formation happens in stages: new fat tissue begins forming at the matrix's edges within weeks, continues throughout the matrix over several months, and gradually replaces the scaffold on a predictable timeline.¹

Both restore volume using adipose tissue, but they take different clinical approaches. Fat transfer uses live fat cells harvested from the patient. Renuva is an off-the-shelf adipose allograft of 100% extracellular matrix that the body gradually replaces with the patient's own fat typically over 3 to 6 months.¹